Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2
نویسندگان
چکیده
منابع مشابه
Roles of GASP-1 and GDF-11 in Dental and Craniofacial Development.
PURPOSE Growth and differentiation factor-11 (GDF-11) is a TGF-β family member that plays important regulatory roles in development of multiple tissues which include axial skeletal patterning, palatal closure, and tooth formation. Proteins that have been identified as GDF-11 inhibitors include GDF-associated serum protein-1 (GASP-1) and GASP-2. Recently, we found that mice genetically engineere...
متن کاملAbsence of hyperplasia in Gasp-1 overexpressing mice is dependent on myostatin up-regulation.
BACKGROUND/AIMS Overexpression of Gasp-1, an inhibitor of myostatin, leads to a hypermuscular phenotype due to hypertrophy rather than hyperplasia in mice. However to date, the cellular and molecular mechanisms underlying this phenotype are not investigated. METHODS Skeletal muscles of overexpressing Gasp-1 mice, called Tg(Gasp-1) mice, were analyzed by histological methods. Satellite cell-de...
متن کاملEnhancement of C2C12 myoblast proliferation and differentiation by GASP-2, a myostatin inhibitor
BACKGROUND GASP-2 is a secreted multi-domain glycoprotein known as a specific inhibitor of myostatin and GDF-11. Here we investigate the role of GASP-2 on myogenesis and the effect of its glycosylation on its activity. METHODS GASP-2 overexpression or knockdown by shRNAs were carried out on C2C12 myoblasts cells. In silico analysis of GASP-2 protein was performed to identify its glycosylation...
متن کاملRegulation of myostatin in vivo by GASP-1: a novel protein with protease inhibitor and follistatin domains
Myostatin, a member of the TGF−β superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene (FLRG). Here, we report the identification of an additional protein associated with endogenous myostatin in normal mouse and human serum, discovered by affinit...
متن کاملSTATIC TIMING ANALYSIS OF GASP by Prasad
Acknowledgements I sincerely thank my advisor, Dr. Peter Beerel for inspiring me to take up one of the most significant academic challenges that I have taken in my life. He has been the best advisor a graduate student can wish for and without his support, guidance and patience; this work would not have been completed. I also thank his wife Janet and baby Kira for considering me as a part of the...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1309907110